Spano P F, Trabucchi M, Di Chiara G
Science. 1977 Jun 17;196(4296):1343-5. doi: 10.1126/science.17159.
Nigral basal adenylate cyclase and dopamine-sensitive adenylate cyclase, glutamate decarboxylase, choline acetyltransferase, and tyrosine hydroxylase activities were measured in rats with hemitransections at various levels or with electrolytic lesions of the medial forebrain bundle or the crus cerebri. The loss of nigral dopamine-sensitive adenylate cyclase activity after the various brain lesions was correlated with loss of nigral glutamic acid decarboxylase but not that of tyrosine hydroxylase; nigral choline acetyltransferase was unaffected in all cases. The data indicate that the nigral dopamine-sensitive adenylate cylase activity may be localized on neurons afferent to the nigra, probably originating from the globus pallidus and possibly from the tail of the caudate. The results suggest that dopamine, released from nigral dendrites, may influence dopaminergic activity indirectly by modulating impulses transmitted to the nigrostriatal neurons through the crus cerebri.
在不同水平进行半横断或内侧前脑束或大脑脚电解损伤的大鼠中，测量黑质基底腺苷酸环化酶、多巴胺敏感性腺苷酸环化酶、谷氨酸脱羧酶、胆碱乙酰转移酶和酪氨酸羟化酶的活性。各种脑损伤后黑质多巴胺敏感性腺苷酸环化酶活性的丧失与黑质谷氨酸脱羧酶活性的丧失相关，但与酪氨酸羟化酶活性的丧失无关；在所有情况下，黑质胆碱乙酰转移酶均未受影响。数据表明，黑质多巴胺敏感性腺苷酸环化酶活性可能定位于黑质传入神经元上，可能起源于苍白球，也可能来自尾状核尾部。结果表明，从黑质树突释放的多巴胺可能通过调节通过大脑脚传递到黑质纹状体神经元的冲动，间接影响多巴胺能活性。
