Ghaffar Omar, Staines W Richard, Feinstein Anthony
Neuropsychiatry Division, Department of Psychiatry, Sunnybrook Health Sciences Centre, FG08-2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
Neurology. 2006 Dec 12;67(11):2036-8. doi: 10.1212/01.wnl.0000247275.68402.fc.
We investigated three subjects with unexplained sensory loss meeting criteria for conversion disorder using brain fMRI during unilateral and bilateral vibrotactile stimulation. In each subject, stimulation of the affected limb did not produce activation of the contralateral primary somatosensory (S1) region, whereas bilateral limb stimulation did. These findings implicate selective alterations in primary sensorimotor cortex activity in conversion disorder, and may also reconcile the discordant results of previous studies.
我们使用脑功能磁共振成像（fMRI）对三名符合转换障碍标准的不明原因感觉丧失患者进行了研究，在单侧和双侧振动触觉刺激期间观察大脑活动。在每名患者中，对患侧肢体的刺激未引起对侧初级体感（S1）区域的激活，而双侧肢体刺激则能引起该区域激活。这些发现表明转换障碍中初级感觉运动皮层活动存在选择性改变，也可能解释先前研究中不一致的结果。
