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[结直肠癌切除术后吻合口瘘:基于我们近期经验的发生率及治疗]

[Anastomotic fistulas after colorectal resection for carcinoma: incidence and treatment in our recent experience].

作者信息

Basilico V, Griffa B, Castiglione N, Giacci F, Zanardo M, Griffa A

机构信息

U.O. Chirurgia Oncologica Gastroenterologica, Dipartimento di Chirurgia, Ospedale Valduce, Como, Italy.

出版信息

Minerva Chir. 2006 Oct;61(5):373-80.

Abstract

AIM

The incidence of anastomotic fistula after colorectal surgery did not significantly change in the literature during the last years, despite the advances in the treatment with the use of surgical staplers. Taking into account this and other considerations, the authors present their recent experience in the surgical treatment of colorectal carcinoma, referring in particular to anastomotic fistula, related postoperative mortality and results of consequent reoperations.

METHODS

From January 1, 2002 to December 31, 2005, 448 patients affected with colorectal cancer were operated on at the Surgical Department of Valduce Hospital in Como, and in 373 cases an anastomosis was performed, subdivided as follows: 144 ileocolic (38.6%), 10 ileorectal (2.7%), 219 colocolic or colorectal (58.7%).

RESULTS

Twenty-five out of 373 anastomotic leaks developed (6.7%). In 9 cases (36%), the fistulas spontaneously closed with conservative treatment, while in 16 (64%) reoperation was necessary. With reference to the anatomical site, the leak occurred in 9 out of 144 patients submitted to right hemicolectomy (6.3%), in 14 out of 219 patients after left hemicolectomy or anterior resection of the rectum (6.4%) and in 2 out of 10 patients (20%) after total colectomy. The following is a detailed report of the therapeutic choices adopted by the authors. Four out of 16 reoperated patients (25%) died postoperatively from infective complications related to the fistula, while the total postoperative mortality was 2.2% (10/448). Therefore, anastomotic dehiscence was responsible for 40% of all postoperative deaths.

CONCLUSIONS

Among all the different operative choices, the authors give their preference to the direct suture of the fistula and loop ileostomy, which they consider the best available choice. The subsequent operation of ileostomy closure is easier for the surgeon to perform and for the patient to withstand than colostomy closure, particularly after Hartmann's operation.

摘要

目的

尽管在使用手术吻合器治疗方面取得了进展,但近年来文献中结直肠手术后吻合口瘘的发生率并未显著变化。考虑到这一点及其他因素,作者介绍了他们近期在结直肠癌手术治疗方面的经验,尤其涉及吻合口瘘、相关术后死亡率及后续再次手术的结果。

方法

2002年1月1日至2005年12月31日,科莫瓦尔杜切医院外科对448例结直肠癌患者进行了手术,其中373例进行了吻合,分类如下:回结肠吻合144例(38.6%),回直肠吻合10例(2.7%),结肠结肠或结肠直肠吻合219例(58.7%)。

结果

373例吻合口中有25例发生渗漏(6.7%)。9例(36%)瘘口经保守治疗自行闭合,16例(64%)需要再次手术。就解剖部位而言,144例行右半结肠切除术的患者中有9例发生渗漏(6.3%),219例行左半结肠切除术或直肠前切除术的患者中有14例发生渗漏(6.4%),10例行全结肠切除术的患者中有2例发生渗漏(20%)。以下是作者采用的治疗选择的详细报告。16例再次手术的患者中有4例(25%)术后死于与瘘相关的感染并发症,而术后总死亡率为2.2%(10/448)。因此,吻合口裂开占所有术后死亡的40%。

结论

在所有不同的手术选择中,作者更倾向于瘘口直接缝合和袢式回肠造口术,他们认为这是目前最好的选择。与结肠造口关闭相比,后续的回肠造口关闭手术对外科医生来说更容易操作,对患者来说也更容易耐受,尤其是在哈特曼手术后。

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