Costa Patrícia Grativol, Saraiva Fábio Petersen, Pereira Ivana Cardoso, Matayoshi Suzana
Departamento de Oftalmologia e Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Arq Bras Oftalmol. 2008 Jul-Aug;71(4):480-5. doi: 10.1590/s0004-27492008000400003.
To compare morphometric data of eyelid fissure using computerized image analysis before and after application of botulinum toxin type A in patients with eyelid retraction caused by dysthyroid orbitopathy in acute stage.
This was a prospective study with 12 individuals that received transcutaneous 5 UI/0.1 ml injection of botulinum toxin in the upper eyelid. They were examined periodically for 6 months. Clinical eyelid examination was performed and recorded using a video camera connected to a microcomputer.
Vertical eyelid fissure, upper eyelid margin to reflex distance and the eyelid area showed reduction in the treated eye. A decrease in the levator function of the upper eyelid was observed, and also, a reduction in the difference between the lateral and medial areas. The lower eyelid margin reflex distance did not show any significant differences after the application. Measurements of the contralateral eye increased up to 2 weeks after the application.
These results showed a reduction in eyelid retraction and improving the upper eyelid contour, without changes in the lower eyelid position.
运用计算机图像分析技术，比较A型肉毒杆菌毒素应用于急性期甲状腺相关眼病所致眼睑退缩患者前后的睑裂形态学数据。
这是一项前瞻性研究，12例患者接受了经皮在上睑注射5单位/0.1毫升肉毒杆菌毒素。对他们进行为期6个月的定期检查。使用连接到微型计算机的摄像机进行临床眼睑检查并记录。
治疗眼的垂直睑裂、上睑缘至反射距离和眼睑面积减小。观察到上睑提肌功能下降，外侧和内侧区域之间的差异也减小。应用后下睑缘反射距离未显示任何显著差异。对侧眼的测量值在应用后2周内增加。
这些结果表明眼睑退缩减少，上睑轮廓改善，而下睑位置无变化。
