Ozkan S B, Can D, Söylev M F, Arsan A K, Duman S
SB Ankara Hospital, Turkey.
Ophthalmologica. 1997;211(6):387-90. doi: 10.1159/000310837.
Upper-eyelid retraction is a common sign of thyroid-associated eye disease (TAED), and these patients are highly bothered by the appearance of their eyes. In this study, botulinum toxin A (BTA) was injected into the levator palpebrae superioris muscle in 8 eyes of 4 patients in an attempt to control the abnormal elevation of the upper eyelid. BTA provided control of the upper-eyelid retraction, and the cosmetically acceptable effect lasted for 3-4 months. It was concluded that BTA is an effective method of treatment in this condition. Since it has a temporary effect, it can safely be used to provide relief of symptoms related to upper-eyelid retraction during unstabilized periods of TAED, which may last as long as several years in some patients.
上睑退缩是甲状腺相关性眼病（TAED）的常见体征，这些患者对自己眼睛的外观深感困扰。在本研究中，对4例患者的8只眼睛的提上睑肌注射了A型肉毒杆菌毒素（BTA），试图控制上睑的异常上抬。BTA可控制上睑退缩，其美容效果可维持3 - 4个月。得出结论，BTA是治疗这种情况的有效方法。由于其效果是暂时的，在TAED不稳定期（在一些患者中可能长达数年），它可安全地用于缓解与上睑退缩相关的症状。
