Worthington R W, Mülders M S
Onderstepoort J Vet Res. 1975 Mar;42(1):25-7.
It was shown that Clostridium perfringens epsilon toxin has the effect of allowing the passage of 125I polyvinyl-pyrrolidone and 125I human serum albumin into mouse brain. These substances did not enter the brains of normal control mice. The passage of albumin into the brains of mice poisoned with epsilon toxin was extremely rapid. When large doses of toxin (+/-4 000 MLD) were given death ensued within 2-3 min at which stage 1,5% of the injected albumin had already entered the brain. In cases where smaller doses were given and the time interval between injection and death was longer the figure was increased to 2-2 1/2% of the injected plasma albumin.
已表明产气荚膜梭菌ε毒素具有使¹²⁵I聚乙烯吡咯烷酮和¹²⁵I人血清白蛋白进入小鼠脑内的作用。这些物质不会进入正常对照小鼠的脑内。白蛋白进入ε毒素中毒小鼠脑内的过程极其迅速。给予大剂量毒素（±4000最小致死量）时，在2 - 3分钟内就会死亡，此时注射的白蛋白已有1.5%进入脑内。给予较小剂量且注射与死亡之间的时间间隔较长时，该比例增至注射血浆白蛋白的2% - 2.5%。
