Riffelmann M, Littmann M, Hülsse C, O'Brien J, Wirsing von König C H
Institut für Infektiologie Krefeld GmbH, Krefeld.
Dtsch Med Wochenschr. 2006 Dec 15;131(50):2829-34. doi: 10.1055/s-2006-957208.
A prospective sentinel study into the population-based incidence of pertussis in adults was done between 2001 and 2004 in Rostock (former East Germany) and Krefeld (former West Germany).
971 outpatients, who consulted general practitioners or internists, were included. Clinical inclusion criteria were coughing for one week or more and no chronic respiratory diseases. Bordetella infection was diagnosed by PCR on nasopharyngeal swabs and ELISA for serology (IgG-anti-PT, IgA-anti-PT, IgG-anti-FHA, IgA-anti-FHA).
We found a total of 97 cases of pertussis in this cohort. The main symptom was coughing for a median of 7-8 weeks. Population-based incidence was estimated in Krefeld at 169 cases/100000 population per year, and in Rostock at 160/100000 per year. Resource use was 120 EUR of direct medical cost and 434 euro of indirect medical cost, not including hospitalization in this study.
Pertussis is a frequent cause of longer lasting cough in German adults, and it causes significant morbidity and costs.
2001年至2004年间，在罗斯托克（原东德）和克雷费尔德（原西德）开展了一项关于成人百日咳人群发病率的前瞻性哨点研究。
纳入971名就诊于全科医生或内科医生的门诊患者。临床纳入标准为咳嗽持续一周或更长时间且无慢性呼吸道疾病。通过对鼻咽拭子进行聚合酶链反应（PCR）以及采用酶联免疫吸附测定法（ELISA）进行血清学检测（抗百日咳毒素IgG、抗百日咳毒素IgA、抗丝状血凝素IgG、抗丝状血凝素IgA）来诊断博德特氏菌感染。
在该队列中总共发现97例百日咳病例。主要症状为咳嗽，中位数持续时间为7 - 8周。克雷费尔德的人群发病率估计为每年每10万人口中有169例，罗斯托克为每年每10万人口中有160例。本研究中资源使用情况为直接医疗费用120欧元，间接医疗费用434欧元，不包括住院费用。
百日咳是德国成人持续性咳嗽的常见病因，会导致显著的发病率和费用。
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