[骨髓增生异常综合征的临床与细胞遗传学分析] （注：原文句首Analysis应改为Analyze才符合语法规范）
[Analysis the clinic and cytogenetics of myelodysplastic syndrome].
作者信息
Cen Ling, Zhou Min, Zhao Ying-hao
机构信息
Department of Blood Laboratory, Changzhou No.2 People's Hospital, Changzhou, Jiangsu, 213003, P. R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Dec;23(6):668-9.
OBJECTIVE
To analysis the relationship among cytogenetics, morphology and prognosis of the myelodysplastic syndrome (MDS) patients.
METHODS
Cytogenetics analysis of bone marrow cells was performed by direct method and/or 24 h culture method. The karyotype was analysed by R banding technique.
RESULTS
Out of the 50 MDS patients, 22 were found with abnormal karyotype: two of them were +8, four of them were -7, four of them were 5q-, nine of them were 7q-, two of them were 20q- and one of them was 6q-. There are six patients had complex changes in chromosome.
CONCLUSION
5q-, -7, 7q- are the most classic translocation in the MDS. The patients with 5q- have better prognosis and the patients with -7, 7q- have worse prognosis. Cytogenetics is very important in the MDS's diagnosis, progress and prognosis.
目的
分析骨髓增生异常综合征（MDS）患者的细胞遗传学、形态学与预后之间的关系。
方法
采用直接法和/或24小时培养法对骨髓细胞进行细胞遗传学分析。通过R显带技术分析核型。
结果
50例MDS患者中，22例核型异常：其中2例为+8，4例为-7，4例为5q-，9例为7q-，2例为20q-，1例为6q-。有6例患者染色体有复杂改变。
结论
5q-、-7、7q-是MDS最典型的易位。5q-患者预后较好，-7、7q-患者预后较差。细胞遗传学在MDS的诊断、病情进展及预后中非常重要。
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