Effect of Toki-shakuyaku-san on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats.

作者信息

Hatip-Al-Khatib Izzettin, Hatip Funda Bölukbaşi, Yoshimitsu Yoshitaka, Iwasaki Katsunori, Egashira Nobuaki, Liu An-Xin, Mishima Kenichi, Fujiwara Michihiro

机构信息

Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Kinikli, Denizli 20070, Turkey.

出版信息

Phytother Res. 2007 Mar;21(3):291-4. doi: 10.1002/ptr.2050.

The effects of Toki-shakuyaku-san (TSS) ingredients on acetylcholine (ACh) release in the dorsal hippocampus (DH) were investigated in intact and twice-repeated ischemic rats using in vivo microdialysis-HPLC. Moreover, the effect of TSS on blood flow was investigated in intact rats using laser Doppler flowmetry. TSS at 300 mg/kg p.o. increased ACh and blood flow after 40 min in intact rats. TSS also increased ACh in ischemic rats but to a lesser extent than in intact rats. These results could suggest that TSS-increased ACh and blood flow in DH may contribute in the cognition improving property of TSS.