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HHV-6 脑病伴出疹期惊厥簇发作

HHV-6 encephalopathy with cluster of convulsions during eruptive stage.

作者信息

Nagasawa Tetsuro, Kimura Ikumi, Abe Yuichi, Oka Akira

机构信息

Department of Neurology, National Center for Child Health and Development, Tokyo, Japan.

出版信息

Pediatr Neurol. 2007 Jan;36(1):61-3. doi: 10.1016/j.pediatrneurol.2006.06.020.

DOI:10.1016/j.pediatrneurol.2006.06.020
PMID:17162201
Abstract

The features of a characteristic type of encephalopathy caused by human herpesvirus-6 are presented. All patients have clusters of brief convulsions during the stage of skin eruptions. Sometimes the encephalopathy resulted in hemiplegia or mental retardation. Because the clinical course is similar, we propose a subtype of encephalopathy "human herpesvirus-6 encephalopathy with cluster of convulsions in eruptive stage" for further studies of pathophysiology and treatment.

摘要

本文介绍了由人类疱疹病毒6型引起的一种特征性脑病的特点。所有患者在皮疹阶段都有短暂惊厥发作的簇状表现。有时该脑病会导致偏瘫或智力发育迟缓。由于临床病程相似,我们提出一种脑病亚型“爆发期有惊厥簇状发作的人类疱疹病毒6型脑病”,以供进一步研究病理生理学和治疗方法。

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引用本文的文献

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Spectrum of Neurological Manifestations of HHV-6 Encephalitis in Immunocompetent Children - A Retrospective Study at a Tertiary Care Center in South India.免疫功能正常儿童中HHV-6脑炎的神经学表现谱——印度南部一家三级护理中心的回顾性研究
Ann Indian Acad Neurol. 2025 May 1;28(3):400-405. doi: 10.4103/aian.aian_717_24. Epub 2025 May 6.
2
Detection frequency of human herpesviruses-6A, -6B, and -7 genomic sequences in central nervous system DNA samples from post-mortem individuals with unspecified encephalopathy.患有未明确脑病的尸检个体中枢神经系统DNA样本中人类疱疹病毒6A、6B和7基因组序列的检测频率
J Neurovirol. 2016 Aug;22(4):488-97. doi: 10.1007/s13365-015-0417-0. Epub 2016 Jan 4.
3
Human herpesviruses 6, 7, and 8 from a dermatologic perspective.
从皮肤科角度看人类疱疹病毒 6、7 和 8。
Mayo Clin Proc. 2012 Oct;87(10):1004-14. doi: 10.1016/j.mayocp.2012.04.010. Epub 2012 Jul 21.
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Review part 2: Human herpesvirus-6 in central nervous system diseases.综述第二部分:中枢神经系统疾病中的人疱疹病毒6型
J Med Virol. 2010 Oct;82(10):1669-78. doi: 10.1002/jmv.21861.
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Differences of clinical manifestations according to the patterns of brain lesions in acute encephalopathy with reduced diffusion in the bilateral hemispheres.双侧半球弥散受限的急性脑病中,根据脑损伤模式的临床表现差异。
AJNR Am J Neuroradiol. 2009 Apr;30(4):825-30. doi: 10.3174/ajnr.A1431. Epub 2009 Jan 8.
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Human herpesvirus 6A (HHV-6A) and HHV-6B alter E2F1/Rb pathways and E2F1 localization and cause cell cycle arrest in infected T cells.人类疱疹病毒6A(HHV - 6A)和HHV - 6B改变E2F1/Rb通路及E2F1定位,并在受感染的T细胞中导致细胞周期停滞。
J Virol. 2007 Dec;81(24):13499-508. doi: 10.1128/JVI.01496-07. Epub 2007 Oct 3.