Division of Clinical Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clin Proc. 2012 Oct;87(10):1004-14. doi: 10.1016/j.mayocp.2012.04.010. Epub 2012 Jul 21.
Human herpesviruses (HHVs) have frequently been suspected as etiologic agents or cofactors in cutaneous disease. However, clearly established associations are rare. Investigations into an etiologic association between HHVs and cutaneous disease are complicated by the ubiquity and nearly universal prevalence of some herpesviruses. This article summarizes the associations between cutaneous disease and HHV-6, HHV-7, and HHV-8. In addition to a personal library of references, the PubMed database of biomedical literature was searched using the following Medical Subject Heading terms: HHV-6, HHV-7, and HHV-8, each in conjunction with cutaneous manifestations, virology, epidemiology, dermatopathology, and therapeutics, between 1998 and March 2011. Free-text searches with known or suspected disease associations were added for broader coverage. The results have been summarized to provide a practical review for the physician likely to encounter cutaneous diseases.
人类疱疹病毒（HHV）常被怀疑为皮肤疾病的病原体或协同因子。然而，明确的关联却很少见。HHV 与皮肤疾病之间的病因关联研究受到一些疱疹病毒普遍存在和几乎普遍流行的影响而变得复杂。本文总结了 HHV-6、HHV-7 和 HHV-8 与皮肤疾病之间的关联。除了个人参考资料库之外，还使用以下医学主题词在生物医学文献 PubMed 数据库中进行了检索：HHV-6、HHV-7 和 HHV-8，分别结合皮肤表现、病毒学、流行病学、皮肤病理学和治疗学，检索时间为 1998 年至 2011 年 3 月。对于更广泛的涵盖范围，还增加了已知或疑似疾病关联的自由文本搜索。总结结果为可能遇到皮肤疾病的医生提供实用的综述。
