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脑脊液置换治疗大剂量阿糖胞苷所致急性小脑功能障碍1例报告

Flushing out of cerebrospinal fluid as a therapy for acute cerebellar dysfunction caused by high dose of cytosine arabinoside: a case report.

作者信息

Pellier Isabelle, Leboucher Bertrand, Rachieru Petronela, Ifrah Norbert, Rialland Xavier

机构信息

Unité d'Hematologie-Immunologie-Oncologie Pédiatrique, CHU Angers, France.

出版信息

J Pediatr Hematol Oncol. 2006 Dec;28(12):837-9. doi: 10.1097/MPH.0b013e31802d3e2d.

DOI:10.1097/MPH.0b013e31802d3e2d
PMID:17164656
Abstract

High dose of cytosine arabinoside is usually used in treatment of acute myelogenous leukemia. Here we report 1 case of a child who developed neurologic toxicity and rapidly improved after flushing out of cerebral spinal fluid, suggesting it could be treatment in the acute phase of toxicity. Efficacy of this treatment could be explained by reducing cytosine arabinoside metabolites in central nervous system.

摘要

高剂量阿糖胞苷通常用于治疗急性髓系白血病。在此我们报告1例儿童发生神经毒性，在进行脑脊液置换后迅速好转，提示这可能是急性毒性期的一种治疗方法。这种治疗的有效性可以通过减少中枢神经系统中阿糖胞苷代谢产物来解释。

相似文献

1
Flushing out of cerebrospinal fluid as a therapy for acute cerebellar dysfunction caused by high dose of cytosine arabinoside: a case report.脑脊液置换治疗大剂量阿糖胞苷所致急性小脑功能障碍1例报告
J Pediatr Hematol Oncol. 2006 Dec;28(12):837-9. doi: 10.1097/MPH.0b013e31802d3e2d.
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"Flushing out" cytosine arabinoside from CSF to reverse neurotoxicity.从脑脊液中“清除”阿糖胞苷以逆转神经毒性。
J Pediatr Hematol Oncol. 2007 Apr;29(4):274. doi: 10.1097/MPH.0b013e318041f134.
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Anterior uveitis associated with high-dose cytosine arabinoside.高剂量阿糖胞苷相关前葡萄膜炎。
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Acute polyneuropathy after high dose cytosine arabinoside in patients with leukemia.
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[Cerebellar toxicity of cytosine-arabinoside in a young man following cerebral anoxia].[一名年轻男性脑缺氧后阿糖胞苷的小脑毒性]
Ann Med Interne (Paris). 1995;146(8):597-8.
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Cerebellar dysfunction during high dose cytosine arabinoside therapy in a case of acute myelogenous leukaemia.一例急性髓细胞白血病患者在大剂量阿糖胞苷治疗期间出现的小脑功能障碍。
Scand J Haematol. 1986 Feb;36(2):165-7. doi: 10.1111/j.1600-0609.1986.tb00822.x.
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[All-trans retinoic acid combined with low-dose cytosine arabinoside treatment for acute myelogenous leukemia with trilineage myelodysplasia--a case report].全反式维甲酸联合小剂量阿糖胞苷治疗伴三系骨髓发育异常的急性髓系白血病——病例报告
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Retreatment with low-dose cytarabine in patients with previous central nervous system toxicity.既往有中枢神经系统毒性的患者采用小剂量阿糖胞苷进行再治疗。
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引用本文的文献

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Neurocognitive deficits in survivors of childhood acute myeloid leukemia.儿童急性髓细胞性白血病幸存者的神经认知缺陷。
BMC Pediatr. 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0.
2
Cytarabine Induced Acute Cerebellar Syndrome during Hyper-CVAD Treatment for B-Cell Acute Lymphoblastic Leukemia.在B细胞急性淋巴细胞白血病的Hyper-CVAD治疗期间，阿糖胞苷诱发急性小脑综合征。
Case Rep Neurol. 2017 May 9;9(1):114-120. doi: 10.1159/000468921. eCollection 2017 Jan-Apr.