C3氟代MEP的对映选择性合成。
Enantioselective synthesis of C3 fluoro-MEP.
作者信息
Ghilagaber Stephanos, Hunter William N, Marquez Rodolfo
机构信息
School of Life Sciences, University of Dundee, DD1 5EH, UK.
出版信息
Org Biomol Chem. 2007 Jan 7;5(1):97-102. doi: 10.1039/b613656g. Epub 2006 Nov 10.
DOI:10.1039/b613656g
PMID:17164912
Abstract
The first enantioselective synthesis of C(3) fluoro-MEP is herein reported. The synthetic pathway developed takes advantage of a selective hydrofluorination of a 2,3-epoxy-1-alcohol to introduce the required tertiary fluoride unit.
摘要
本文报道了C(3)氟代MEP的首次对映选择性合成。所开发的合成途径利用了2,3-环氧-1-醇的选择性氢氟化反应来引入所需的叔氟单元。
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