在由植物血凝素或爱泼斯坦-巴尔病毒诱导的有丝分裂后，人淋巴细胞上HL-A抗原的表达增强。
Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.
作者信息
McCune J M, Humphreys R E, Yocum R R, Strominger J L
出版信息
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3206-9. doi: 10.1073/pnas.72.8.3206.
Abstract
The amount of HL-A antigens present on the peripheral blood lymphocytes of a single human donor was increased about 11-fold after stimulation with phytohemagglutinin and 36-fold after transformation with Epstein-Barr virus. This increase applied to all four HL-A specificities of these cells. The response to phytohemagglutinin was dependent on dose and was first observed at 12 hr of incubation. Measurements of the amount of surface membranes by geometry, by radioiodinatable surface proteins, and by 5'-nucleotidase (5'-ribonucleotide phosphohydrolase, EC 3.1.3.5) assay all indicated that the enhanced representation of HL-A antigens after stimulation by phytohemagglutinin or transformation by Epstein-Barr virus must be due to an increase in the density of these antigens on the cell surface.
摘要
单个人类供体外周血淋巴细胞上存在的HL-A抗原量，在用植物血凝素刺激后增加了约11倍，在用爱泼斯坦-巴尔病毒转化后增加了36倍。这种增加适用于这些细胞的所有四种HL-A特异性。对植物血凝素的反应取决于剂量，在孵育12小时时首次观察到。通过几何学、可放射性碘化的表面蛋白以及5'-核苷酸酶（5'-核糖核苷酸磷酸水解酶，EC 3.1.3.5）测定法对表面膜量进行的测量均表明，植物血凝素刺激或爱泼斯坦-巴尔病毒转化后HL-A抗原的增强表达必定是由于这些抗原在细胞表面的密度增加所致。
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Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.在由植物血凝素或爱泼斯坦-巴尔病毒诱导的有丝分裂后，人淋巴细胞上HL-A抗原的表达增强。
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