Maggi C A, Patacchini R, Feng D M, Folkers K
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Eur J Pharmacol. 1991 Jun 18;199(1):127-9. doi: 10.1016/0014-2999(91)90648-a.
We compared the ability of spantide I and II to antagonize tachykinins in monoreceptor bioassays. Both peptides antagonized the response to substance P methylester in the guinea-pig ileum (NK-1 receptor-mediated) with greater affinity than the responses mediated by NK-2 or NK-3 receptors in other bioassays. Spantide II was about 10 times more potent than spantide I as an NK-1 antagonist and also possessed some selectivity for the NK-2 receptor subtype present in the hamster trachea. Spantide II is a suitable tool to assess the role of NK-1 receptors in the central and peripheral nervous system.
