斯潘肽 III，一种具有高效力和可忽略神经毒性的高级速激肽拮抗剂。

Spantide III, a superior tachykinin antagonist with high potency and negligible neurotoxicity.

机构信息

Institute for Biomedical Research, University of Texas at Austin, 78712, Austin, TX, USA.

出版信息

Amino Acids. 1993 Jun;5(2):233-8. doi: 10.1007/BF00805985.

PMID:24190666

Abstract

Five new antagonists of Substance P were designed and synthesized toward increasing potency and safety. One of them was more effective than Spantide II, which was the basis for the design. It was named Spantide III and has the structure: D-NicLys,Pro,Pal,Pro,D-Cl2Phe,Asn,D-Trp,Phe,D-Pal,Leu, NleNH2.

摘要

设计并合成了 5 种新的 P 物质拮抗剂，旨在提高其效力和安全性。其中一种比 Spantide II 更有效，Spantide II 是设计的基础。它被命名为 Spantide III，其结构为：D-NicLys，Pro，Pal，Pro，D-Cl2Phe，Asn，D-Trp，Phe，D-Pal，Leu，NleNH2。