铜（I）催化的对映选择性和非对映选择性串联还原羟醛反应。
Copper(I)-catalyzed enantio- and diastereoselective tandem reductive aldol reaction.
作者信息
Chuzel Olivier, Deschamp Julia, Chausteur Christophe, Riant Olivier
机构信息
Unité de chimie organique et médicinale, Université catholique de Louvain, Place Louis Pasteur, 1, 1348 Louvain-la-Neuve, Belgium.
出版信息
Org Lett. 2006 Dec 21;8(26):5943-6. doi: 10.1021/ol062398v.
[Structure: see text] An efficient method for the enantioselective tandem reductive aldol reaction of methyl acrylate with aldehydes is reported. By using a copper(I) precursor and a proper diphosphane ligand, high reactivities can be reached, with TOF up to 40,000 h-1. Taniaphos-based ligands lead to enantioselectivities of up to 97% in the case of the major syn diastereoisomer.
[结构：见正文] 报道了一种用于丙烯酸甲酯与醛的对映选择性串联还原羟醛反应的有效方法。通过使用铜（I）前体和合适的二膦配体，可以实现高反应活性，TOF高达40,000 h-1。在主要的顺式非对映异构体的情况下，基于Taniaphos的配体可导致高达97%的对映选择性。
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