血清中可溶性Fcε受体II（sFcεRII/CD23）的意义及sFcεRII在预防过敏反应中的可能应用。
Significance of soluble Fc epsilon receptor II (sFc epsilon RII/CD23) in serum and possible application of sFc epsilon RII for the prevention of allergic reactions.
作者信息
Suemura M, Kikutani H, Sugiyama K, Uchibayashi N, Aitani M, Kuritani T, Barsumian E L, Yamatodani A, Kishimoto T
机构信息
Third Department of Internal Medicine, Osaka University, Japan.
出版信息
Allergy Proc. 1991 May-Jun;12(3):133-7.
The significance of sFc epsilon RII in IgE-mediated allergic disease was examined. sFc epsilon RII in serum was found to decrease following clinical improvement, suggesting sFc epsilon RII in serum may be an indicator of allergic diseases. Significant proportions of sFc epsilon RII in serum were present as complexes with IgE in normals as well as in atopic patients, and these complexes were more prominent in the former than in the latter group. From these observations, attempts were made to inhibit IgE-mediated allergic reactions in vitro employing recombinant sFc epsilon RII. sFc epsilon RII inhibited IgE-binding as well as IgE-mediated release of chemical mediators from Fc epsilon RI and Fc epsilon RII expressing cells. These results show the functional significance of sFc epsilon RII in the negative regulation of IgE-mediated allergic reactions.
研究了可溶性FcεRII在IgE介导的过敏性疾病中的意义。发现血清中的可溶性FcεRII在临床症状改善后会降低，这表明血清中的可溶性FcεRII可能是过敏性疾病的一个指标。在正常人和特应性患者中，血清中相当一部分可溶性FcεRII以与IgE的复合物形式存在，且这些复合物在前者中比在后者中更显著。基于这些观察结果，尝试使用重组可溶性FcεRII在体外抑制IgE介导的过敏反应。可溶性FcεRII抑制了IgE结合以及FcεRI和FcεRII表达细胞中IgE介导的化学介质释放。这些结果显示了可溶性FcεRII在IgE介导的过敏反应负调节中的功能意义。
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