Kim K M, Nanbu M, Iwai Y, Tanaka M, Yodoi J, Mayumi M, Mikawa H
Department of Pediatrics, Faculty of Medicine, Kyoto University, Japan.
Pediatr Res. 1989 Jul;26(1):49-53. doi: 10.1203/00006450-198907000-00015.
IgE-binding factors are thought to have regulatory activity in in vitro IgE synthesis. To obtain evidence of the participation of IgE-binding factors in in vivo IgE synthesis, the serum level of low affinity Fc receptors for IgE (sFc epsilon RII) (IgE-BFs) was examined in 41 nonallergic children and in 37 allergic children whose serum IgE levels were significantly higher than those of nonallergic children. The serum level of sFc epsilon RII showed a marked age-dependent variation. It was highest in infants and then decreased gradually with age. The serum level of sFc epsilon RII in allergic children was significantly higher than that of nonallergic children in early childhood (1128.0 +/- 323.8 vs 777.3 +/- 227.0 pg/ml, p less than 0.01 in infants (less than 1 y) and 851.8 +/- 270.0 vs 579.4 +/- 197.1 pg/ml, p less than 0.05 in children aged 1-2 y) but not in older children (3-15 y). Three allergic infants (less than 1 y) with serum sFc epsilon RII levels higher than the mean + 1 SD (1451.8 pg/ml) of all allergic infants (less than 1 y) had serum IgE levels (geometric mean 125.9 IU/ml) significantly higher than the other seven allergic infants (less than 1 y) (geometric mean 5.6 IU/ml, p less than 0.05). A close positive correlation between the serum level of sFc epsilon RII and the absolute number of Fc epsilon RII(+) peripheral blood lymphocytes was observed (Spearman's rank correlation coefficient = 0.79, p less than 0.001 in 27 allergic and Spearman's rank correlation coefficient = 0.72, p less than 0.001 in 19 nonallergic children). In conclusion, serum sFc epsilon RII may be derived mainly from Fc epsilon RII(+) lymphocytes, and may have relationship to the increased production of IgE in early childhood (0-2 y).
IgE结合因子被认为在体外IgE合成中具有调节活性。为了获得IgE结合因子参与体内IgE合成的证据，对41名非过敏性儿童和37名血清IgE水平显著高于非过敏性儿童的过敏性儿童检测了IgE低亲和力Fc受体（sFcεRII）（IgE结合因子）的血清水平。sFcεRII的血清水平呈现出明显的年龄依赖性变化。在婴儿期最高，然后随着年龄逐渐下降。在幼儿期，过敏性儿童的sFcεRII血清水平显著高于非过敏性儿童（婴儿期（小于1岁）：1128.0±323.8对777.3±227.0 pg/ml，p<0.01；1 - 2岁儿童：851.8±270.0对579.4±197.1 pg/ml，p<0.05），但在大龄儿童（3 - 15岁）中并非如此。三名血清sFcεRII水平高于所有过敏性婴儿（小于1岁）平均值 + 1标准差（1451.8 pg/ml）的过敏性婴儿（小于1岁），其血清IgE水平（几何平均值125.9 IU/ml）显著高于其他七名过敏性婴儿（小于1岁）（几何平均值5.6 IU/ml，p<0.05）。观察到sFcεRII血清水平与FcεRII(+)外周血淋巴细胞绝对数之间存在密切的正相关（27名过敏性儿童中Spearman等级相关系数 = 0.79，p<0.001；19名非过敏性儿童中Spearman等级相关系数 = 0.72，p<0.001）。总之，血清sFcεRII可能主要来源于FcεRII(+)淋巴细胞，并且可能与幼儿期（0 - 2岁）IgE产生增加有关。
