上尿路移行细胞癌患者的生存分析：开放与手辅助腹腔镜肾输尿管切除术的比较

Survival analysis in patients with upper urinary tract transitional cell carcinoma: a comparison between open and hand-assisted laparoscopic nephroureterectomy.

作者信息

Hsueh Thomas Y, Huang Yi-Hsiu, Chiu Allen W, Huan Steven K, Lee Ying-Huei

机构信息

Department of Urology at Taipei City Hospital, Zhongxiao branch, and National Yang-Ming University, School of Medicine, Taipei, Taiwan.

出版信息

BJU Int. 2007 Mar;99(3):632-6. doi: 10.1111/j.1464-410X.2006.06665.x. Epub 2006 Dec 13.

DOI:10.1111/j.1464-410X.2006.06665.x

PMID:17166239

Abstract

OBJECTIVE

To evaluate the stage- and grade-specific survival rate in patients with upper urinary tract (UUT) transitional cell carcinoma (TCC) after open (ONU) or hand-assisted laparoscopic nephroureterectomy (LNU) with bladder-cuff excision.

PATIENTS AND METHODS

From January 1998 to April 2005, 143 patients with UUT-TCC were treated with either ONU or LNU and enrolled in the study. The peri-operative data were collected by retrospective chart review. The recurrence, metastasis and survival rate were calculated.

RESULTS

The 5-year disease-specific survival of patients with pT1 disease was 88.1% after ONU and 92.0% after LNU (P = 0.745); the respective values for patients with pT2 were 11/17 and 12/15 (P = 0.874), and for pT3 were six/11 and 12/15 (P = 0.476). The incidence of bladder recurrence within 2 years after surgery was 24.7% for ONU and 19.7% for LNU (P = 0.475).

CONCLUSION

The results were similar after ONU or LNU with bladder-cuff excision; bladder-cuff excision using a hand-assisted device is effective and serves as a treatment option for patients with UUT-TCC.

摘要

目的

评估开放性上尿路（UUT）移行细胞癌（TCC）行开放性肾输尿管切除术（ONU）或手辅助腹腔镜肾输尿管切除术（LNU）并切除膀胱袖口状组织后各分期及分级患者的生存率。

患者与方法

1998年1月至2005年4月，143例UUT-TCC患者接受了ONU或LNU治疗并纳入本研究。通过回顾性病历审查收集围手术期数据。计算复发率、转移率和生存率。

结果

pT1期疾病患者ONU术后5年疾病特异性生存率为88.1%，LNU术后为92.0%（P = 0.745）；pT2期患者分别为11/17和12/15（P = 0.874），pT3期患者分别为6/11和12/15（P = 0.476）。术后2年内ONU组膀胱复发率为24.7%，LNU组为19.7%（P = 0.475）。