Hwang Seon Hee, Kwon Jun Soo, Shin Yong-Wook, Lee Kyung Jin, Kim Young Youn, Kim Myung-Sun
Clinical Research Center, Seoul National University Hospital, Seoul, South Korea.
J Int Neuropsychol Soc. 2007 Jan;13(1):30-7. doi: 10.1017/S1355617707070063.
In this study, we assess the neuropsychological profiles of both early and late symptom-onset obsessive-compulsive disorder (OCD) patients. The early and late-onset OCD patients are compared to the control group with a series of neuropsychological measurements. The late-onset OCD patients exhibited impaired performance on the immediate and the delayed recall conditions of the Rey-Osterrieth Complex Figure Test (RCFT) and the letter and category fluency of the Controlled Oral Word Association Test (COWA), compared to the normal controls and the early-onset OCD patients. The controls and early-onset OCD patients did not differ on any of the neuropsychological measurements taken in this study. These results suggest that different neurophysiological mechanisms are in play in early and late-onset OCD patients, and age of onset can serve as a potential marker for the subtyping of OCD.
在本研究中，我们评估了早发型和晚发型强迫症（OCD）患者的神经心理学特征。通过一系列神经心理学测量，将早发型和晚发型OCD患者与对照组进行比较。与正常对照组和早发型OCD患者相比，晚发型OCD患者在雷-奥斯特里思复杂图形测验（RCFT）的即时和延迟回忆条件以及受控口语联想测验（COWA）的字母流畅性和类别流畅性方面表现受损。在本研究中进行的任何神经心理学测量中，对照组和早发型OCD患者均无差异。这些结果表明，早发型和晚发型OCD患者存在不同的神经生理机制，发病年龄可作为OCD亚型分类的潜在标志物。
