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Longterm remission of multiple brain metastases with tamoxifen.

作者信息

Pors H, von Eyben F E, Sørensen O S, Larsen M

机构信息

Department of Internal Medicine, County Hospital, Nakskov, Denmark.

出版信息

J Neurooncol. 1991 Apr;10(2):173-7. doi: 10.1007/BF00146879.

DOI:10.1007/BF00146879
PMID:1716670
Abstract

A case of multiple brain metastases from breast carcinoma treated with tamoxifen is described. She remained in remission for 58 months and is still alive after 82+ months of hormone therapy. The case indicates that hormonal treatment may be very effective in the management of brain metastases from breast carcinoma.

摘要

相似文献

1
Longterm remission of multiple brain metastases with tamoxifen.
J Neurooncol. 1991 Apr;10(2):173-7. doi: 10.1007/BF00146879.
2
Complete remission of a brain metastasis to third-line hormonal treatment with megestrol acetate.脑转移瘤经三线醋酸甲地孕酮激素治疗后完全缓解。
Am J Clin Oncol. 1990 Dec;13(6):507-9. doi: 10.1097/00000421-199012000-00011.
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4
[A case of brain metastasis from breast cancer responding to chemoendocrine therapy].
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5
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6
[Which hormone therapy should be used in advanced breast carcinoma in males?].男性晚期乳腺癌应使用哪种激素疗法？
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[Ablative hormone therapy and chemotherapy of metastatic breast cancer].
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Interaction between Estrogen Receptors and p53: A Broader Role for Tamoxifen?雌激素受体与p53之间的相互作用：他莫昔芬的作用更广泛？
Endocrinology. 2025 Feb 5;166(3). doi: 10.1210/endocr/bqaf020.
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Breast Cancer Brain Metastasis: A Comprehensive Review.乳腺癌脑转移：全面综述。
JCO Oncol Pract. 2024 Oct;20(10):1348-1359. doi: 10.1200/OP.23.00794. Epub 2024 May 15.
3
Anti-Hormonal Therapy in Breast Cancer and Its Effect on the Blood-Brain Barrier.乳腺癌的抗激素治疗及其对血脑屏障的影响。

本文引用的文献

1
Brain metastases from breast cancer: clinical course, prognosis and influence of treatment.乳腺癌脑转移：临床病程、预后及治疗的影响
Clin Oncol. 1981 Dec;7(4):291-301.
2
Hypothalamic, pituitary and uterine cytoplasmic and nuclear oestrogen receptors and their relationship to the serum concentration of tamoxifen and its metabolite, 4-hydroxytamoxifen, in the ovariectomized rat.去卵巢大鼠下丘脑、垂体及子宫的细胞质和细胞核雌激素受体及其与他莫昔芬及其代谢产物4-羟基他莫昔芬血清浓度的关系。
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Cancers (Basel). 2022 Oct 19;14(20):5132. doi: 10.3390/cancers14205132.
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Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases.乳腺癌脑和软脑膜转移的全身治疗方法。
Curr Treat Options Oncol. 2022 Oct;23(10):1457-1476. doi: 10.1007/s11864-022-01011-w. Epub 2022 Sep 22.
5
Intracranial Response Rate in Patients with Breast Cancer Brain Metastases after Systemic Therapy.全身治疗后乳腺癌脑转移患者的颅内缓解率
Cancers (Basel). 2022 Feb 15;14(4):965. doi: 10.3390/cancers14040965.
6
Is Molecular Tailored-Therapy Changing the Paradigm for CNS Metastases in Breast Cancer?分子靶向治疗是否正在改变乳腺癌中枢神经系统转移的治疗模式？
Clin Drug Investig. 2021 Sep;41(9):757-773. doi: 10.1007/s40261-021-01070-1. Epub 2021 Aug 17.
7
Tamoxifen suppresses brain metastasis of estrogen receptor-deficient breast cancer by skewing microglia polarization and enhancing their immune functions.他莫昔芬通过改变小胶质细胞极化状态并增强其免疫功能抑制雌激素受体阴性乳腺癌脑转移。
Breast Cancer Res. 2021 Mar 18;23(1):35. doi: 10.1186/s13058-021-01412-z.
8
Treatment strategies for breast cancer brain metastases.乳腺癌脑转移的治疗策略。
Br J Cancer. 2021 Jan;124(1):142-155. doi: 10.1038/s41416-020-01175-y. Epub 2020 Nov 30.
9
Systemic Therapy of Central Nervous System Metastases of Breast Cancer.乳腺癌中枢神经系统转移的全身治疗。
Curr Oncol Rep. 2019 Apr 8;21(6):49. doi: 10.1007/s11912-019-0802-6.
10
Brain metastases from breast cancer may respond to endocrine therapy: report of two cases.乳腺癌脑转移可能对内分泌治疗有反应：两例报告。
Onco Targets Ther. 2019 Feb 19;12:1389-1393. doi: 10.2147/OTT.S188143. eCollection 2019.
[乳腺癌患者中枢神经系统转移的特征与治疗]
Gan No Rinsho. 1984 Jul;30(9 Suppl):987-93.
4
Tamoxifen-induced regression of cerebral metastases in breast carcinoma.他莫昔芬诱导乳腺癌脑转移灶消退
Cancer Treat Rep. 1981 Sep-Oct;65(9-10):793-5.
5
Chemotherapy induces regression of brain metastases in breast carcinoma.化疗可使乳腺癌脑转移灶消退。
Cancer. 1986 Aug 15;58(4):832-9. doi: 10.1002/1097-0142(19860815)58:4<832::aid-cncr2820580404>3.0.co;2-w.
6
Bilateral optic neuritis evolved during tamoxifen treatment.在他莫昔芬治疗期间发生了双侧视神经炎。
Cancer. 1986 Jul 15;58(2):383-6. doi: 10.1002/1097-0142(19860715)58:2<383::aid-cncr2820580232>3.0.co;2-i.
7
Combination chemotherapy compared to tamoxifen as initial therapy for stage IV breast cancer in elderly women.
Ann Intern Med. 1986 Apr;104(4):455-61. doi: 10.7326/0003-4819-104-4-455.
8
Neurologic, neuropsychologic, and computed cranial tomography scan abnormalities in 2- to 10-year survivors of small-cell lung cancer.小细胞肺癌2至10年存活者的神经、神经心理及头颅计算机断层扫描异常情况。
J Clin Oncol. 1985 Dec;3(12):1659-67. doi: 10.1200/JCO.1985.3.12.1659.