Narr Katherine L, Bilder Robert M, Luders Eileen, Thompson Paul M, Woods Roger P, Robinson Delbert, Szeszko Philip R, Dimtcheva Teodora, Gurbani Mala, Toga Arthur W
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA.
Neuroimage. 2007 Feb 1;34(3):939-48. doi: 10.1016/j.neuroimage.2006.08.052. Epub 2006 Dec 12.
Some evidence suggests that sex, handedness and disease processes associated with schizophrenia affect the magnitude and/or direction of structural brain asymmetries. There are mixed findings, however, on how these factors influence cerebral torque, when torque is assessed with linear or volumetric measurements. We obtained MRI data from 67 healthy (30 males, 10 non-dextrals) and 84 schizophrenia subjects (60 males; 16 non-dextrals) and applied cortical pattern matching to spatially relate and compare differences in the surface morphology of the two cerebral hemispheres at high spatial resolution. Asymmetry indices, computed at thousands of matched hemispheric locations, were used to examine effects of sex, handedness and schizophrenia on hemispheric shape asymmetries while controlling for age and the other factors. Highly significant and discriminative right-frontal and left parietal-occipital surface expansions and protrusions (petalias) were mapped within groups. Although hemispheric shape asymmetries appeared less pronounced within female non-dextrals, asymmetry indices were not shown to differ significantly across sex, hand preference or diagnosis, or to reveal interactions of handedness with sex or diagnosis. Our 3D maps of spatially detailed anterior and posterior hemispheric shape asymmetries reflect subtle geometric distortions in hemispheric surface morphology that cannot be characterized with 2D or volumetric methods. Inter-individual variations in hemispheric torque appear minimally influenced by sex, dextrality or disease status. Biological factors driving language dominance or other lateralized brain functions dissociable from handedness, may more closely relate to hemispheric shape asymmetries, while the lateralization of other discrete brain regions may be more influenced by sexually dimorphic factors or by schizophrenia pathophysiology.
一些证据表明，性别、利手以及与精神分裂症相关的疾病过程会影响大脑结构不对称的程度和/或方向。然而，当通过线性或体积测量来评估扭矩时，关于这些因素如何影响大脑扭矩，研究结果并不一致。我们获取了67名健康受试者（30名男性，10名非右利手者）和84名精神分裂症患者（60名男性；16名非右利手者）的MRI数据，并应用皮质模式匹配在高空间分辨率下对两个大脑半球的表面形态差异进行空间关联和比较。在数千个匹配的半球位置计算不对称指数，以检验性别、利手和精神分裂症对半球形状不对称的影响，同时控制年龄和其他因素。在各群体中绘制出了具有高度显著性和区分性的右侧额叶和左侧顶枕叶表面扩展及突出（脑叶优势）。尽管在女性非右利手者中半球形状不对称似乎不太明显，但不对称指数并未显示在性别、利手偏好或诊断之间存在显著差异，也未揭示利手与性别或诊断之间的相互作用。我们的三维空间详细的前后半球形状不对称图谱反映了半球表面形态中无法用二维或体积方法表征的细微几何扭曲。半球扭矩的个体间差异似乎受性别、右利手性或疾病状态的影响最小。驱动语言优势或其他与利手无关的大脑功能侧化的生物学因素，可能与半球形状不对称关系更为密切，而其他离散脑区的侧化可能更多地受两性异形因素或精神分裂症病理生理学的影响。
