Shevah O, Laron Z
Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, 14 Kaplan Street, Petah-Tikva 49202, Israel.
Growth Horm IGF Res. 2007 Feb;17(1):54-7. doi: 10.1016/j.ghir.2006.10.007. Epub 2006 Dec 12.
Overexpression of IGF-I occurs in tumors diagnosed in childhood (osteosarcoma, Wilms tumor, neuroblastoma, etc.) and in adults (breast, ovaries, colon and prostate cancer). The aim of our study was to establish the prevalence of malignancies in states of congenital IGF-I deficiency.
We surveyed 222 patients with congenital IGF-I deficiency (Laron syndrome, GH gene deletion, GHRH receptor defects and IGF-I resistance) and 338 first and second-degree relatives.
None of the IGF-I deficient patients had cancer, whereas 9-24% of the family members had a history of malignancy.
Congenital IGF-I deficiency acts as a protecting factor for the development of cancer.
胰岛素样生长因子-I（IGF-I）过表达出现在儿童期诊断出的肿瘤（骨肉瘤、肾母细胞瘤、神经母细胞瘤等）以及成人肿瘤（乳腺癌、卵巢癌、结肠癌和前列腺癌）中。我们研究的目的是确定先天性IGF-I缺乏状态下恶性肿瘤的患病率。
我们调查了222例先天性IGF-I缺乏患者（拉伦综合征、生长激素基因缺失、生长激素释放激素受体缺陷和IGF-I抵抗）以及338名一级和二级亲属。
IGF-I缺乏患者中无人患癌症，而9%-24%的家庭成员有恶性肿瘤病史。
先天性IGF-I缺乏是癌症发生发展的保护因素。
