Sims A-M, Barnardo M, Herzberg I, Bradbury L, Calin A, Wordsworth B P, Darke C, Brown M A
Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.
Genes Immun. 2007 Mar;8(2):115-23. doi: 10.1038/sj.gene.6364362. Epub 2006 Dec 14.
Ankylosing spondylitis (AS) has been associated with human leukocyte antigen (HLA)-B27 for over 30 years; however, the mechanism of action has remained elusive. Although many studies have reported associations between AS and other genes in the major histocompatibility complex (MHC) in AS, no conclusive results have emerged. To investigate the contribution of non-B27 MHC genes to AS, a large cohort of AS families and controls were B27 typed and genotyped across the region. Interrogation of the data identified a region of 270 kb, lying from 31 952 649 to 32 221 738 base pairs from the p-telomere of chromosome 6 and containing 23 genes, which is likely to include genes involved with susceptibility to AS.
强直性脊柱炎（AS）与人类白细胞抗原（HLA）-B27相关已有30多年；然而，其作用机制仍不清楚。尽管许多研究报告了AS与主要组织相容性复合体（MHC）中的其他基因之间的关联，但尚未得出确凿结果。为了研究非B27 MHC基因对AS的作用，对一大群AS家族和对照进行了B27分型和该区域的基因分型。对数据的审查确定了一个270 kb的区域，位于6号染色体p端粒的31 952 649至32 221 738碱基对之间，包含23个基因，其中可能包括与AS易感性相关的基因。
