Gonzalez-Martinez Jorge A, Guthikonda Murali, Vellutini Eduardo, Zamorano Lucia, Li Qinghang, Kupski William, Diaz Fernando G
Skull Base. 2002 Aug;12(3):155-61. doi: 10.1055/s-2002-33462.
Chordomas are rare tumors of the central nervous system and primarily occur in the extradural space. We report two patients with intracranial chordomas located in the region of the clivus that invaded the prepontine cisterns. The patients, 45 and 62 years old, had histories of cranial neuropathies and headache, respectively. Petrosal approaches were performed in both with radical resection of the tumors. Anatomopathological studies confirmed the diagnosis of chordoma. The symptoms of both patients resolved, and they have had no recurrence after 18 months of follow-up. Intradural chordomas or extradural chordomas that invade the intradural space are difficult to differentiate from ecchordoses physaliphorae, a non-neoplastic entity with similar radiological features. MBI-1 studies were therefore performed to confirm the diagnosis of chordoma. The differential diagnosis for these two entities, the different modalities of treatment, and prognosis are reviewed.
脊索瘤是中枢神经系统的罕见肿瘤，主要发生在硬膜外间隙。我们报告了两名颅内脊索瘤患者，肿瘤位于斜坡区域并侵犯脑桥前池。这两名患者分别为45岁和62岁，分别有颅神经病变和头痛病史。两人均采用岩骨入路并根治性切除肿瘤。解剖病理学研究证实为脊索瘤。两名患者的症状均得到缓解，随访18个月后均无复发。硬膜内脊索瘤或侵犯硬膜内间隙的硬膜外脊索瘤很难与脊索样脑膜膨出相鉴别，后者是一种具有相似放射学特征的非肿瘤性病变。因此进行了MBI-1研究以确诊脊索瘤。本文对这两种病变的鉴别诊断、不同治疗方式及预后进行了综述。
