Beatty W W, O'Briant D A, Vilberg T R
Pharmacol Biochem Behav. 1975 Jul-Aug;3(4):539-44. doi: 10.1016/0091-3057(75)90169-0.
Female rats with lesions of the ventromedial hypothalamus (VMH) were ovariectomized during the static obese stage after body weight levels had stabilized. Following ovariectomy, rats with VMH lesions showed smaller increases in food intake and less body weight gain than non-lesioned controls ovariectomized at the same time. Subsequently, the effects of peripheral injections of estradiol benzoate (EB) on feeding and body weight were examined. Ovariectomized rats with VHM lesions were also less responsive to exogenous EB treatment; they lost significantly less weight in response to estrogen than controls. EB caused a somewhat smaller reduction in food intake by the VMH group but this difference was not significant. Considered together the available data on changes in responsiveness to endogenous and exogenous estrogen following VMH lesions suggest a role for VMH estrogen receptors in the regulation of body weight, but these estrogen receptors may not modulate weight by directly altering food intake as previously suggested.
在体重水平稳定后的静态肥胖阶段，对患有腹内侧下丘脑（VMH）损伤的雌性大鼠进行卵巢切除术。卵巢切除术后，与同时进行卵巢切除术的未损伤对照组相比，患有VMH损伤的大鼠食物摄入量增加较小，体重增加也较少。随后，研究了外周注射苯甲酸雌二醇（EB）对进食和体重的影响。患有VHM损伤的卵巢切除大鼠对外源性EB治疗的反应也较小；与对照组相比，它们对雌激素的反应导致体重减轻明显较少。EB使VMH组的食物摄入量减少幅度略小，但这种差异不显著。综合考虑VMH损伤后对内源性和外源性雌激素反应性变化的现有数据表明，VMH雌激素受体在体重调节中起作用，但这些雌激素受体可能不像之前所认为的那样通过直接改变食物摄入量来调节体重。
