Lashuel Hilal A, Hirling Harald
Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Station 15, CH-1015 Lausanne, Switzerland.
ACS Chem Biol. 2006 Aug 22;1(7):420-4. doi: 10.1021/cb600331e.
Studies in yeast are providing critical insights into the mechanisms of neurodegeneration in Parkinson's disease (PD). A recent study shows that disruption of vesicular trafficking between the endoplasmic reticulum (ER) and the Golgi, caused by the overexpression and/or aggregation of alpha-synuclein, is linked to degeneration of dopamine neurons. Overexpression of proteins that are known to enhance ER-to-Golgi transport rescue defective trafficking in yeast, worm, fly, and cellular models of PD.
对酵母的研究正在为帕金森病（PD）神经退行性变机制提供关键见解。最近一项研究表明，由α-突触核蛋白的过度表达和/或聚集导致的内质网（ER）与高尔基体之间囊泡运输的破坏与多巴胺能神经元的变性有关。已知增强ER到高尔基体运输的蛋白质的过表达可挽救酵母、蠕虫、果蝇和PD细胞模型中的缺陷运输。
