Sugano Masayoshi, Shintani Yoichi, Kobayashi Keiko, Sakakibara Noriyuki, Isomura Iwao, Morita Akimichi
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
J Dermatol. 2006 Dec;33(12):887-91. doi: 10.1111/j.1346-8138.2006.00203.x.
Discoid lupus erythematosus (DLE), a cutaneous form of lupus erythematosus, is characterized as atrophic and scaly erythema and the lesions are often refractory to a wide range of topical or systemic therapies. Herein, we present four cases of DLE that were successfully treated with topical tacrolimus. Tacrolimus ointment (0.1%) was applied to DLE lesions twice daily and the erythematous plaques readily diminished after 4-8 weeks. Adverse effects, such as burning sensation or irritations, were not observed. These results indicate that topical tacrolimus might be an effective and alternative treatment to control DLE.
盘状红斑狼疮（DLE）是红斑狼疮的一种皮肤形式，其特征为萎缩性和鳞屑性红斑，并且这些皮损通常对多种局部或全身治疗均难以治愈。在此，我们报告4例使用局部他克莫司成功治疗的DLE病例。将他克莫司软膏（0.1%）每日两次涂抹于DLE皮损处，4至8周后红斑斑块迅速消退。未观察到诸如烧灼感或刺激等不良反应。这些结果表明，局部他克莫司可能是控制DLE的一种有效且可替代的治疗方法。
