Dunicz-Sokolowska A, Graczyk A, Radomska K, Długaszek M, Wlaźlak E, Surkont G
Polish Academy of Sciences, System Research Institute, ul. Newelska 6, 01-447 Warsaw, Poland.
Magnes Res. 2006 Sep;19(3):167-79.
The aim of this study was to define referential values of 5 basic bioelements (Ca, Mg, Zn, Cu, Fe) in the hair of Polish young persons aged 10-20 years, based on the research conducted from 1991 to 2004 on a group of over 3420 healthy young persons. Mean concentrations of two toxic metals (Pb and Cd) in over 2000 young men were also investigated. The results of biochemical tests were analyzed with the program STATISTICA 7.0 (StatSoft PL). Significant differences between girls' and boys' hair Ca, Mg and Zn in the same age group were observed (p = 0.0000). It was determined that boys have smaller concentrations of hair Ca, Mg and Zn than girls. No significant differences were observed between concentrations of Cu and Fe in the hair of girls and boys of the same age in the tested period. Significantly greater amounts of Pb and Cd characterize boys. Analyses of correlations confirm significance (p < 0.05000) of synergistic interactions between bioelements: Ca-Mg (r = +0.80), Ca-Zn (r = +0.52), Ca-Cu (r = +0.14), Mg-Zn (r = +0.50), Mg-Cu (r = +0.13), Zn-Cu (r = +0.11), Cu-Fe (r = +0.04). Significance (p < 0.05000) of antagonistic interactions of bioelements with toxic metals: Zn-Pb (r = -0.30), Mg-Pb (r = -0.20), Ca-Pb (r = -0.18) and Zn-Cd (r = -0.07) was confirmed. Significance (p < 0.05000) of synergistic effects with toxic elements: Pb-Cd (r = +0.34), Fe-Pb (r = +0.22), Fe-Cd (r = +0.13) was determined. Compatibility of the statistically mapped basic characteristics of young persons' developmental age with the functions of concentrations in tested hair bioelements was confirmed. Young persons whose concentrations of selected hair bioelements showed values outside the reference ranges and who had higher concentrations of toxic metals should undergo further diagnostic tests since the results of previous tests could be a sign of disturbances leading to various diseases. Analyses of the concentrations of bioelements and toxic metals in humans based on hair analysis can be useful as a convenient, non-invasive and painless method in the diagnosis of pathological states. Combined with other analytical data, this method can be used by practising physicians as a complementary diagnostic procedure.
本研究的目的是根据1991年至2004年对3420多名健康年轻人进行的研究，确定10至20岁波兰年轻人头发中5种基本生物元素（钙、镁、锌、铜、铁）的参考值。还对2000多名年轻男性体内两种有毒金属（铅和镉）的平均浓度进行了调查。生化测试结果使用STATISTICA 7.0程序（StatSoft PL）进行分析。观察到同一年龄组女孩和男孩头发中的钙、镁和锌存在显著差异（p = 0.0000）。确定男孩头发中的钙、镁和锌浓度低于女孩。在测试期间，同一年龄的女孩和男孩头发中的铜和铁浓度未观察到显著差异。男孩体内的铅和镉含量明显更高。相关性分析证实了生物元素之间协同相互作用的显著性（p < 0.05000）：钙 - 镁（r = +0.80）、钙 - 锌（r = +0.52）、钙 - 铜（r = +0.14）、镁 - 锌（r = +0.50）、镁 - 铜（r = +0.13）、锌 - 铜（r = +0.11）、铜 - 铁（r = +0.04）。生物元素与有毒金属拮抗相互作用的显著性（p < 0.05000）也得到证实：锌 - 铅（r = -0.30）、镁 - 铅（r = -0.20）、钙 - 铅（r = -0.18）和锌 - 镉（r = -0.07）。还确定了与有毒元素协同作用的显著性（p < 0.05000）：铅 - 镉（r = +0.34）、铁 - 铅（r = +0.22）、铁 - 镉（r = +0.13）。证实了年轻人发育年龄的统计学映射基本特征与测试头发生物元素浓度功能的兼容性。所选头发生物元素浓度显示值超出参考范围且有毒金属浓度较高的年轻人应接受进一步的诊断测试，因为先前测试的结果可能是导致各种疾病的紊乱迹象。基于头发分析对人体生物元素和有毒金属浓度进行分析，作为一种方便、无创且无痛的病理状态诊断方法可能会有所帮助。结合其他分析数据，这种方法可供执业医生用作补充诊断程序。
