Cohen A S, Goadsby P J
Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
J Neurol Neurosurg Psychiatry. 2007 Jan;78(1):96-7. doi: 10.1136/jnnp.2006.096651.
Chronic paroxysmal hemicrania (CPH) is a rare primary headache syndrome, which is classified along with cluster headache and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) as a trigeminal autonomic cephalalgia. CPH is exquisitely responsive to indomethacin so much so that the response is one of the current diagnostic criteria. The case of a patient with CPH, who had marked epigastric symptoms with indomethacin treatment and responded well to topiramate 150 mg daily, is reported. Cessation of topiramate caused return of episodes, and the response has persisted for 2 years. Topiramate may be a treatment option in CPH.
慢性发作性偏侧头痛(CPH)是一种罕见的原发性头痛综合征,它与丛集性头痛以及伴有结膜充血和流泪的短暂性单侧神经痛样头痛发作(SUNCT)一起被归类为三叉自主神经性头痛。CPH对吲哚美辛极为敏感,以至于这种反应是目前的诊断标准之一。本文报告了一例CPH患者,该患者在接受吲哚美辛治疗时出现明显的上腹部症状,而每日服用150毫克托吡酯后反应良好。停用托吡酯导致发作复发,且这种反应持续了2年。托吡酯可能是CPH的一种治疗选择。