Enia G
Unità Operativa di Nefrologia Dialisi e Trapianto Renale e CNR-IBIM, Istituto di Biomedicina, Azienda Ospedaliera, Reggio Calabria.
G Ital Nefrol. 2006 Nov-Dec;23(6):569-74.
Peritoneal dialysis doses were prescribed out of empirical criteria up to the mid-Ninety Then, the observational CANUSA study and the experimental ADEMEX study helped to define adequacy criteria according to urea kinetics model. This review analyzes the limits of a definition of adequacy grounded exclusively on urea kinetics, as well as the need for new parameters of adequacy. The evidence is presented fostering the hypothesis that the control of extra-cellular fluid excess and of other cardiovascular risk factors may now be considered a new target for adequacy.
直到九十年代中期，腹膜透析剂量一直是根据经验标准来规定的。随后，观察性的CANUSA研究和实验性的ADEMEX研究有助于根据尿素动力学模型确定充分性标准。本综述分析了仅基于尿素动力学的充分性定义的局限性，以及对新的充分性参数的需求。文中提出的证据支持了这样一种假设，即控制细胞外液过多和其他心血管危险因素现在可被视为充分性的一个新目标。
