Eg5加快行动！
Eg5 steps it up!
作者信息
Valentine Megan T, Fordyce Polly M, Block Steven M
机构信息
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
出版信息
Cell Div. 2006 Dec 15;1:31. doi: 10.1186/1747-1028-1-31.
Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division. Recent measurements have shown that one mitotic kinesin superfamily member, Eg5, is mechanically processive and capable of crosslinking and sliding microtubules in vitro. In this review, we highlight recent work that explores how Eg5 functions under load, with an emphasis on the nanomechanical properties of single enzymes.
了解分子马达如何在有丝分裂中产生力并移动微管对于理解细胞分裂的物理机制至关重要。最近的测量表明，一种有丝分裂驱动蛋白超家族成员Eg5具有机械持续性，并且能够在体外交联和滑动微管。在这篇综述中，我们重点介绍了探索Eg5在负载下如何发挥作用的最新研究，尤其关注单个酶的纳米力学特性。
Zotero 插件