绿茶的抗疟特性。
Antimalarial properties of green tea.
作者信息
Sannella Anna Rosa, Messori Luigi, Casini Angela, Francesco Vincieri Franco, Bilia Anna Rita, Majori Giancarlo, Severini Carlo
机构信息
Department of Infectious, Parasitic and Immunomediated Diseases, Vector-Borne Diseases and International Health Section, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
出版信息
Biochem Biophys Res Commun. 2007 Feb 2;353(1):177-81. doi: 10.1016/j.bbrc.2006.12.005. Epub 2006 Dec 11.
We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies.
我们在此表明，绿茶粗提物及其两种主要成分表没食子儿茶素-3-没食子酸酯（EGCG）和表儿茶素没食子酸酯（ECG）在体外能强烈抑制恶性疟原虫的生长。发现这两种儿茶素均可增强青蒿素的抗疟作用，且不干扰叶酸途径。鉴于未来的治疗策略，对这些发现的重要性及其机制意义进行了讨论。
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