Philipson L, Sorrentino V
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany.
J Cell Biochem. 1991 Jun;46(2):95-101. doi: 10.1002/jcb.240460202.
Since the introduction of the cell cycle concept two approaches to study growth regulation of cells have been proposed. One claims that cells are naturally quiescent, requiring a stimulatory encouter with growth factors for induction of cell division. The other considers cellular multiplication as the natural steady-state; cessation of multiplication is thus a restriction imposed on the system. In the latter case emphasis is mainly on the signals involved in arrest of multiplication. This Prospect focuses on specific events occurring in mammalian cells at growth arrest, senescence, and terminal differentiation, specifically emphasizing the growth inhibitory factors, tumor suppressor genes, and other signals for growth suppression.
自从细胞周期概念提出以来，已经出现了两种研究细胞生长调控的方法。一种观点认为，细胞天然处于静止状态，需要与生长因子发生刺激性接触才能诱导细胞分裂。另一种观点则将细胞增殖视为自然的稳态；因此，增殖的停止是对该系统施加的一种限制。在后一种情况下，重点主要放在与增殖停止相关的信号上。本综述聚焦于哺乳动物细胞在生长停滞、衰老和终末分化过程中发生的特定事件，特别强调生长抑制因子、肿瘤抑制基因以及其他生长抑制信号。
