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[神经病理性疼痛治疗的新的、相关的及实用方面]

[New, relevant and practical aspects of the treatment of neuropathic pain].

作者信息

Oteo-Alvaro A, Marín M T

机构信息

Departamento de Cirugía Ortopédica y Traumatología, Hospital Virgen de la Torre, Madrid, España.

出版信息

Rev Clin Esp. 2006 Dec;206(11):570-2. doi: 10.1157/13096307.

Abstract

In the Spanish population it is difficult to calculate the prevalence of neuropathic pain (NP) although it is estimated that it is present in 40% of the cases of chronic pain. The treatment is not easy and we must choose between the different drugs, the most appropriate taking into account the effectivity in data from clinical trials, releaf of comorbidities associated to NP and less side effects. In this way, the Finnerup NB's work establishes an algorithm of treatment of NP and it is very helpful for clinicians in order to choose the most suitable treatment. In this work, the author recommends antiepileptic drugs, like gabapentin and pregabalin as first choice treatments. Amitriptiline, a tricycle antidepressant and opioids must be used only when there is a lack of response or intolerance.

摘要

在西班牙人群中,尽管据估计神经性疼痛(NP)在40%的慢性疼痛病例中存在,但很难计算其患病率。治疗并不容易,我们必须在不同药物之间进行选择,要根据临床试验数据中的有效性、与NP相关的合并症的缓解情况以及较少的副作用来选择最合适的药物。通过这种方式,芬内鲁普·NB的研究建立了一种NP治疗算法,这对临床医生选择最合适的治疗方法非常有帮助。在这项研究中,作者推荐抗癫痫药物,如加巴喷丁和普瑞巴林作为首选治疗药物。只有在缺乏反应或不耐受时才必须使用三环类抗抑郁药阿米替林和阿片类药物。

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