Xu Huansheng, Baldini Antonio
Institute of Biosciences and Technology, Texas A&M University System, Houston, TX 77030, United States.
Semin Cell Dev Biol. 2007 Feb;18(1):77-83. doi: 10.1016/j.semcdb.2006.11.011. Epub 2006 Nov 24.
Mammalian heart development requires multiple genetic networks, only some of which are becoming known in all their complexity. Substantial new information has become available thanks to an expanding toolkit that offers more and more mouse gene manipulation options, and that is taking the mouse closer to more powerful invertebrate genetic models. We review examples of recent data with a cardiac-lineage-based view of heart development, especially outflow tract and right ventricle. The medical significance of these studies is not only relevant to congenital heart disease, but also to the biology of cardiac cell regeneration.
哺乳动物心脏发育需要多个基因网络,其中只有一部分的全部复杂性已为人所知。由于不断扩展的工具集提供了越来越多的小鼠基因操作选项,并且使小鼠更接近功能强大的无脊椎动物遗传模型,大量新信息得以获取。我们从基于心脏谱系的心脏发育视角,尤其是流出道和右心室,回顾近期数据的实例。这些研究的医学意义不仅与先天性心脏病相关,还与心脏细胞再生生物学相关。