Black Brian L
Cardiovascular Research Institute and Department of Biochemistry and Biophysics, Mail Code 2240, University of California, San Francisco, California 94158-2517, USA.
Semin Cell Dev Biol. 2007 Feb;18(1):67-76. doi: 10.1016/j.semcdb.2007.01.001. Epub 2007 Jan 17.
The heart is the first organ to form and function during vertebrate development and is absolutely essential for life. The left ventricle is derived from the classical primary or first heart field (FHF), while the right ventricle and outflow tract are derived from a distinct second heart field (SHF). The recent discovery of the SHF has raised several fundamental and important questions about how the two heart fields are integrated into a single organ and whether unique molecular programs control the development of the two heart fields. This review briefly highlights the contributions of the SHF to the developing and mature heart and then focuses primarily on our current understanding of the transcriptional pathways that function in the development of the SHF and its derivatives.
心脏是脊椎动物发育过程中第一个形成并开始发挥功能的器官，对生命至关重要。左心室源自经典的原代或第一心脏区域（FHF），而右心室和流出道则源自一个不同的第二心脏区域（SHF）。SHF的最新发现引发了几个关于两个心脏区域如何整合为一个单一器官以及是否有独特的分子程序控制两个心脏区域发育的基本且重要的问题。本综述简要强调了SHF对发育中和成熟心脏的贡献，然后主要聚焦于我们目前对在SHF及其衍生物发育中起作用的转录途径的理解。
