Vlooswijk M C G, Majoie H J M, De Krom M C T F M, Tan I Y, Aldenkamp A P
Department of Neurology, University Hospital Maastricht, The Netherlands.
Seizure. 2007 Mar;16(2):153-9. doi: 10.1016/j.seizure.2006.11.002. Epub 2006 Dec 18.
To evaluate risk factors for sudden and unexpected death in epilepsy (SUDEP) in a high-risk population, i.e. patients treated in a Dutch tertiary referral center for epilepsy.
All patients who died between January 1999 and April 2004 while under treatment of the epilepsy center were identified. Based on clinical data, deaths were classified as definite, probable, possible or non-SUDEP. Potential risk factors were compared in SUDEP cases and non-SUDEP cases.
SUDEP incidence was 1.24 per 1000 patient years. SUDEP patients died at a younger age than patients from the control group of non-SUDEP deaths with epilepsy and had an earlier onset of epilepsy. However, the frequently mentioned factors in previous studies, i.e. male sex, generalized tonic-clonic seizures, high seizure frequency, specific AEDs, polytherapy with several AEDs, mental retardation, psychiatric illness and psychotropic comedication, were not found to be correlated with SUDEP.
Even in this high-risk population of patients with refractory epilepsy, treated in a tertiary referral center, SUDEP is not a frequently occurring phenomenon. Specific risk factors could not be identified within an already high-risk population.
评估高危人群（即在荷兰一家三级癫痫转诊中心接受治疗的患者）癫痫性猝死（SUDEP）的危险因素。
确定1999年1月至2004年4月期间在癫痫中心接受治疗时死亡的所有患者。根据临床数据，将死亡分为确诊、很可能、可能或非SUDEP。比较SUDEP病例和非SUDEP病例中的潜在危险因素。
SUDEP发病率为每1000患者年1.24例。SUDEP患者的死亡年龄低于癫痫非SUDEP死亡对照组的患者，且癫痫发病较早。然而，先前研究中经常提到的因素，即男性、全身强直阵挛发作、高癫痫发作频率、特定抗癫痫药物、多种抗癫痫药物联合治疗、智力低下、精神疾病和精神药物合并使用，均未发现与SUDEP相关。
即使在这家三级转诊中心接受治疗的难治性癫痫高危人群中，SUDEP也不是常见现象。在已经属于高危的人群中无法确定具体的危险因素。
