临床怀疑冠心病患者的主动脉病理生理学：心血管磁共振研究
Aortic pathophysiology by cardiovascular magnetic resonance in patients with clinical suspicion of coronary artery disease.
作者信息
Auseon Alex J, Tran Tam, Garcia Anne M, Hardy Christopher J, Valavalkar Prajakta, Moeschberger Melvin, Raman Subha V
机构信息
Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA.
出版信息
J Cardiovasc Magn Reson. 2007;9(1):43-8. doi: 10.1080/10976640600897377.
PURPOSE
To correlate cardiovascular magnetic resonance (CMR)-based measurement of aortic pulse wave velocity (PWV) with serum markers for atherosclerosis and plaque burden in the thoracic aorta.
METHOD
Individuals with risk factors for coronary atherosclerosis underwent CMR pulse wave velocity examination of the descending thoracic aorta and computed tomography for coronary calcium scoring. Inversion recovery images allowed quantification of aortic plaque. Serum lipids and c-reactive protein levels were measured.
RESULTS
Mean PWV did not correlate with presence of aortic plaque (p = 0.55). Subgroup analysis showed no significant correlation with PWV and total plaque. PWV and pulse pressure correlated (PP) (R2 0.38, p = 0.0003), but PWV and other predictor variables did not. Total plaque area correlated with aortic diameter (p = 0.0066).
CONCLUSIONS
In patients with suspected coronary artery disease, aortic pulse wave velocity reflects increased aortic stiffness demonstrated by elevated pulse pressure, but does not directly correlate with aortic plaque or serum markers for arterial disease.
目的
将基于心血管磁共振（CMR）的主动脉脉搏波速度（PWV）测量值与动脉粥样硬化血清标志物及胸主动脉斑块负荷相关联。
方法
对有冠状动脉粥样硬化危险因素的个体进行胸降主动脉CMR脉搏波速度检查及冠状动脉钙化积分计算机断层扫描。反转恢复图像可对主动脉斑块进行定量分析。测量血清脂质和C反应蛋白水平。
结果
平均PWV与主动脉斑块的存在无相关性（p = 0.55）。亚组分析显示PWV与总斑块无显著相关性。PWV与脉压（PP）相关（R2 0.38，p = 0.0003），但PWV与其他预测变量不相关。总斑块面积与主动脉直径相关（p = 0.0066）。
结论
在疑似冠状动脉疾病的患者中，主动脉脉搏波速度反映了脉压升高所表明的主动脉僵硬度增加，但与主动脉斑块或动脉疾病血清标志物无直接相关性。
Zotero 插件