甲氟喹对健康男性志愿者青蒿琥酯药代动力学影响的评估。
Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.
作者信息
Davis Timothy M E, England Michelle, Dunlop Anne-Marie, Page-Sharp Madhu, Cambon Nathalie, Keller Thomas G, Heidecker János L, Ilett Kenneth F
机构信息
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia.
出版信息
Antimicrob Agents Chemother. 2007 Mar;51(3):1099-101. doi: 10.1128/AAC.01253-06. Epub 2006 Dec 18.
Abstract
The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.
摘要
在20名志愿者中评估了甲氟喹对青蒿琥酯药代动力学的影响。这些志愿者先接受3天的青蒿琥酯治疗，21天或更长时间后接受3天的联合治疗。青蒿琥酯的活性代谢产物双氢青蒿素在两个给药期第3天的0小时至无穷大浓度-时间曲线下面积相似（P = 0.12），这意味着不存在相互作用。
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