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Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria.用于单纯性恶性疟联合治疗的新甲氟喹方案的群体药代动力学评估。
Antimicrob Agents Chemother. 2006 Jul;50(7):2281-5. doi: 10.1128/AAC.00040-06.
2
Artemisinin-based combinations.基于青蒿素的联合疗法。
Curr Opin Infect Dis. 2005 Dec;18(6):531-6. doi: 10.1097/01.qco.0000186848.46417.6c.
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Pharmacokinetics of the four combination regimens of dihydroartemisinin/mefloquine in acute uncomplicated falciparum malaria.
Southeast Asian J Trop Med Public Health. 2005 Jan;36(1):23-33.
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Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.抗疟青蒿素类药物通过激活异源传感孕烷X受体和组成型雄甾烷受体诱导细胞色素P450和多药耐药蛋白1表达。
Mol Pharmacol. 2005 Jun;67(6):1954-65. doi: 10.1124/mol.104.009019. Epub 2005 Mar 10.
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Artemisinin-based combination therapies for uncomplicated malaria.基于青蒿素的联合疗法治疗非复杂性疟疾。
Med J Aust. 2005 Feb 21;182(4):181-5. doi: 10.5694/j.1326-5377.2005.tb06650.x.
6
Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers.青蒿琥酯和双氢青蒿素的相对生物利用度：在离体灌注大鼠肝脏及健康白种人志愿者中的研究
Am J Trop Med Hyg. 2002 Feb;66(2):130-6. doi: 10.4269/ajtmh.2002.66.130.
7
Pharmacokinetic interactions of antimalarial agents.抗疟药的药代动力学相互作用。
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Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria.静脉注射青蒿琥酯治疗重症恶性疟的药代动力学与药效学
Antimicrob Agents Chemother. 2001 Jan;45(1):181-6. doi: 10.1128/AAC.45.1.181-186.2001.
9
Population pharmacokinetics of mefloquine in patients with acute falciparum malaria.甲氟喹在急性恶性疟患者中的群体药代动力学。
Clin Pharmacol Ther. 1999 Nov;66(5):472-84. doi: 10.1016/S0009-9236(99)70010-X.
10
Comparative clinical trial of four regimens of dihydroartemisinin-mefloquine in multidrug-resistant falciparum malaria.双氢青蒿素-哌喹四种方案治疗耐多药恶性疟的比较临床试验
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甲氟喹对健康男性志愿者青蒿琥酯药代动力学影响的评估。

Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.

作者信息

Davis Timothy M E, England Michelle, Dunlop Anne-Marie, Page-Sharp Madhu, Cambon Nathalie, Keller Thomas G, Heidecker János L, Ilett Kenneth F

机构信息

School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia.

出版信息

Antimicrob Agents Chemother. 2007 Mar;51(3):1099-101. doi: 10.1128/AAC.01253-06. Epub 2006 Dec 18.

DOI:10.1128/AAC.01253-06
PMID:17178798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1803145/
Abstract

The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.

摘要

在20名志愿者中评估了甲氟喹对青蒿琥酯药代动力学的影响。这些志愿者先接受3天的青蒿琥酯治疗，21天或更长时间后接受3天的联合治疗。青蒿琥酯的活性代谢产物双氢青蒿素在两个给药期第3天的0小时至无穷大浓度-时间曲线下面积相似（P = 0.12），这意味着不存在相互作用。