G72/G30基因与精神分裂症：关联研究的系统荟萃分析
G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies.
作者信息
Li Dawei, He Lin
机构信息
Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China.
出版信息
Genetics. 2007 Feb;175(2):917-22. doi: 10.1534/genetics.106.061796. Epub 2006 Dec 18.
Abstract
Schizophrenia may result from a neurotransmission hypofunction of glutamatergic and N-methyl-d-aspartate (NMDA) receptors. Linkage disequilibrium mapping has identified several promising and novel positional candidates, including the G72/G30 and d-amino-acid oxidase (DAAO) genes. Since the first positive association report, many subsequent studies have attempted to replicate the association but the results have been mixed. To try to resolve this inconsistency and to elucidate the relationship between the important glutamate-related genes and schizophrenia, the current meta-analysis has combined samples involving 16 polymorphisms covering all published case-control and family-based association studies up to October 2005. The results suggest that there is weak evidence of association between the G72/G30 genes and schizophrenia.
摘要
精神分裂症可能源于谷氨酸能和N-甲基-D-天冬氨酸（NMDA）受体的神经传递功能减退。连锁不平衡定位已确定了几个有前景的新的位置候选基因，包括G72/G30和D-氨基酸氧化酶（DAAO）基因。自首次阳性关联报告以来，许多后续研究试图重复这种关联，但结果不一。为了解决这种不一致性并阐明重要的谷氨酸相关基因与精神分裂症之间的关系，当前的荟萃分析合并了涉及16种多态性的样本，这些样本涵盖了截至2005年10月所有已发表的病例对照研究和基于家系的关联研究。结果表明，G72/G30基因与精神分裂症之间存在微弱的关联证据。
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