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Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia.荟萃分析表明，神经调节蛋白1（NRG1）基因与精神分裂症存在强烈的正相关。
Hum Mol Genet. 2006 Jun 15;15(12):1995-2002. doi: 10.1093/hmg/ddl122. Epub 2006 May 10.
2
G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis.精神分裂症和双相情感障碍中的G72/G30：综述与荟萃分析。
Biol Psychiatry. 2006 Jul 15;60(2):106-14. doi: 10.1016/j.biopsych.2006.01.019. Epub 2006 Apr 11.
3
Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses.利用系统等位基因和基因型荟萃分析进一步阐明色氨酸羟化酶（TPH）基因对自杀行为的影响。
Hum Genet. 2006 Apr;119(3):233-40. doi: 10.1007/s00439-005-0113-x. Epub 2006 Feb 1.
4
Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis.基于人群和基于家系的5-羟色胺转运体基因多态性与双相情感障碍的研究：一项系统综述和荟萃分析。
Mol Psychiatry. 2005 Aug;10(8):771-81. doi: 10.1038/sj.mp.4001663.
5
No evidence for association to the G72/G30 locus in an independent sample of schizophrenia families.在一个独立的精神分裂症家族样本中，没有证据表明与G72/G30基因座存在关联。
Mol Psychiatry. 2005 May;10(5):431-3. doi: 10.1038/sj.mp.4001619.
6
The neurodevelopmental model of schizophrenia: update 2005.精神分裂症的神经发育模型：2005年更新
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7
A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population.一项关于中国人群中G72/G30基因与精神分裂症关联的家系研究。
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9
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Biol Psychiatry. 2004 Aug 1;56(3):169-76. doi: 10.1016/j.biopsych.2004.04.006.
10
The genes for schizophrenia: finally a breakthrough?精神分裂症的基因：终于有突破了吗？
Curr Psychiatry Rep. 2004 Aug;6(4):303-12. doi: 10.1007/s11920-004-0081-1.

G72/G30基因与精神分裂症：关联研究的系统荟萃分析

G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies.

作者信息

Li Dawei, He Lin

机构信息

Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China.

出版信息

Genetics. 2007 Feb;175(2):917-22. doi: 10.1534/genetics.106.061796. Epub 2006 Dec 18.

DOI:10.1534/genetics.106.061796
PMID:17179078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1800627/
Abstract

Schizophrenia may result from a neurotransmission hypofunction of glutamatergic and N-methyl-d-aspartate (NMDA) receptors. Linkage disequilibrium mapping has identified several promising and novel positional candidates, including the G72/G30 and d-amino-acid oxidase (DAAO) genes. Since the first positive association report, many subsequent studies have attempted to replicate the association but the results have been mixed. To try to resolve this inconsistency and to elucidate the relationship between the important glutamate-related genes and schizophrenia, the current meta-analysis has combined samples involving 16 polymorphisms covering all published case-control and family-based association studies up to October 2005. The results suggest that there is weak evidence of association between the G72/G30 genes and schizophrenia.

摘要

精神分裂症可能源于谷氨酸能和N-甲基-D-天冬氨酸（NMDA）受体的神经传递功能减退。连锁不平衡定位已确定了几个有前景的新的位置候选基因，包括G72/G30和D-氨基酸氧化酶（DAAO）基因。自首次阳性关联报告以来，许多后续研究试图重复这种关联，但结果不一。为了解决这种不一致性并阐明重要的谷氨酸相关基因与精神分裂症之间的关系，当前的荟萃分析合并了涉及16种多态性的样本，这些样本涵盖了截至2005年10月所有已发表的病例对照研究和基于家系的关联研究。结果表明，G72/G30基因与精神分裂症之间存在微弱的关联证据。