Brisch Ralf, Bernstein Hans-Gert, Krell Dieter, Stauch Renate, Trübner Kurt, Dobrowolny Henrik, Kropf Siegfried, Bielau Hendrik, Bogerts Bernhard
Dept. of Psychiatry, Psychotherapy and Psychosomatic Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Eur Arch Psychiatry Clin Neurosci. 2007 Apr;257(3):140-8. doi: 10.1007/s00406-006-0697-8. Epub 2006 Dec 16.
MRI and post-mortem studies indicate an increased prevalence of cavum septi pellucidi (CSP) in schizophrenia and affective disorder. The aim of this study was to characterize the CSP and the septal tissue among patients with schizophrenia, patients with affective disorder, and control subjects. The volumes of CSP and septal tissue were measured in post-mortem brains in 42 patients with schizophrenia, 14 patients with affective disorder, and 17 normal control cases by planimetry of serial sections. Enlargements of CSP (>100 mm(3)) were found in eight of the 42 (19%) patients with schizophrenia. There were no significant differences in CSP volumes between patients with affective disorder and controls. Enlarged CSP in schizophrenia were not associated with reduced septal tissue volumes. By contrast, a significant positive correlation between volumes of CSP and septal tissue volumes in patients with schizophrenia (P = 0.03) and in control cases (P < 0.01) was found, but not in patients with affective disorder (P = 0.53). The finding of enlarged CSP in schizophrenia strongly supports the hypothesis of an early developmental abnormality in this key structure of the limbic system.
磁共振成像（MRI）和尸检研究表明，精神分裂症和情感障碍患者中透明隔腔（CSP）的患病率增加。本研究的目的是描述精神分裂症患者、情感障碍患者和对照受试者中CSP及隔区组织的特征。通过对连续切片进行面积测量，在42例精神分裂症患者、14例情感障碍患者和17例正常对照者的尸检大脑中测量了CSP和隔区组织的体积。42例精神分裂症患者中有8例（19%）发现CSP增大（>100 mm³）。情感障碍患者与对照组之间的CSP体积无显著差异。精神分裂症患者中增大的CSP与隔区组织体积减少无关。相比之下，在精神分裂症患者（P = 0.03）和对照者（P < 0.01）中发现CSP体积与隔区组织体积呈显著正相关，但在情感障碍患者中未发现（P = 0.53）。精神分裂症患者中CSP增大的发现有力地支持了边缘系统这一关键结构存在早期发育异常的假说。
