Shvemberger I N
Tsitologiia. 1975 Oct;17(10):1189-93.
12 rat liver tumors (high, purely and low differentiated hepatomas and adenocarcinomas), 3 kidney tumors, 1 lymphosarcoma and 1 round cell sarcoma of the uterus were transplanted and passed trough anterior chamber of the allogenic rat eyes. In 8 primary transplants of the liver tumors differentiation traits increased; three of them were morphologically undistinguishable from the normal liver tissue. In some transplants of embryonic liver and kidney displasia was detected. The results obtained give evidence in favor of a very high cytological variability of tumors at the early steps of progression, and indicate that the cultivation in the anterior chamber of the eye may be a proper model for investigation of cytological variability of both malignant and normal tissues.
将12个大鼠肝肿瘤（高分化、纯分化和低分化肝癌及腺癌）、3个肾肿瘤、1个淋巴肉瘤和1个子宫圆形细胞肉瘤移植到同种异体大鼠眼前房并传代。在8次肝肿瘤的初次移植中，分化特征增强；其中3个在形态上与正常肝组织无法区分。在一些胚胎肝和肾移植中检测到发育异常。所获得的结果证明肿瘤在进展早期具有非常高的细胞学变异性，并表明眼前房培养可能是研究恶性和正常组织细胞学变异性的合适模型。
