倾斜：膜中甾醇有序排列能力的主要因素。
Tilt: major factor in sterols' ordering capability in membranes.
作者信息
Aittoniemi Jussi, Róg Tomasz, Niemelä Perttu, Pasenkiewicz-Gierula Marta, Karttunen Mikko, Vattulainen Ilpo
机构信息
Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, Finland.
出版信息
J Phys Chem B. 2006 Dec 28;110(51):25562-4. doi: 10.1021/jp064931u.
PMID:17181184
Abstract
Using extensive atomistic simulations, we show that there is a single experimentally accessible parameter--the sterol tilt--that can be used to determine a sterol's capability to induce order, and thus to promote, e.g., formation of lipid rafts. The observations also facilitate designing new effective sterols.
摘要
通过广泛的原子模拟，我们发现有一个单一的实验可获取参数——甾醇倾斜度，它可用于确定甾醇诱导有序性的能力，进而促进例如脂筏的形成。这些观察结果也有助于设计新型有效的甾醇。
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