Matsuzaki H, Shima K, Muramatsu T, Ro Y, Hashimoto S, Shibahara T, Shimono M
Department of Pathology, Tokyo Dental College, Chiba, Japan.
J Oral Pathol Med. 2007 Jan;36(1):30-4. doi: 10.1111/j.1600-0714.2006.00493.x.
Osteopontin (OPN) expression in squamous cell carcinoma (SCC) of the tongue has not been clearly elucidated.
We selected 46 cases of tongue SCC and investigated the expression of OPN by immunohistochemical staining. The immunopositive reaction and score for each case were semiquantitatively evaluated.
Scores were significantly higher in carcinoma nests than in neighboring normal epithelium or epithelial dysplasia. The OPN was expressed clearly in the cytoplasm of carcinoma cells. In cases of early invasive carcinoma, in particular, expression of OPN showed a remarkable increase at the invasion front compared with the non-invaded regions. However, there was no significant correlation between expression of OPN in the primary tumor nest and lymphatic metastasis, recurrence, or survival rate.
This suggests that OPN is a useful biomarker of early invasion by SCC in tongue.
舌鳞状细胞癌（SCC）中骨桥蛋白（OPN）的表达尚未明确阐明。
我们选取了46例舌SCC病例，通过免疫组织化学染色研究OPN的表达。对每例的免疫阳性反应和评分进行半定量评估。
癌巢中的评分显著高于相邻的正常上皮或上皮发育异常。OPN在癌细胞的细胞质中清晰表达。特别是在早期浸润癌病例中，与未浸润区域相比，OPN在浸润前沿的表达显著增加。然而，原发性肿瘤巢中OPN的表达与淋巴转移、复发或生存率之间无显著相关性。
这表明OPN是舌SCC早期浸润的有用生物标志物。
