Mardani Maryam, Andisheh-Tadbir Azadeh, Khademi Bijan, Fattahi Mohammad Javad, Shafiee Shapour, Asad-Zadeh Maryam
Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Tumour Biol. 2014 Apr;35(4):3827-9. doi: 10.1007/s13277-013-1506-4. Epub 2013 Dec 14.
Osteopontin (OPN) is a multifunctional glycophosphoprotein that was detected in many carcinomas, and it may have a prognostic role. The aim of this study was to determine osteopontin serum levels in patients with oral squamous cell carcinoma (OSCC) and investigated its correlation with clinicopathological features of tumor. Using an ELISA kit, we assessed and compared the circulating levels of OPN in blood serum of 45 oral squamous cell carcinoma patients with 45 healthy control samples. The serum osteopontin level in patients with OSCC was significantly higher (145.8 ± 14.6 ng/ml, n = 45) compared with the healthy controls (53.9 ± 9.6 ng/ml, n = 45, p < 0.001). Mean serum osteopontin level was significantly higher in patients with nodal metastasis (p = 0.03) and higher stage (p = 0.02). Findings of the present study suggest that OPN may have a potential role in pathogenesis of OSCC and it may be used as a tool for monitoring tumor progression.
骨桥蛋白（OPN）是一种多功能糖磷蛋白，在许多癌症中均可检测到，并且可能具有预后作用。本研究的目的是测定口腔鳞状细胞癌（OSCC）患者血清中的骨桥蛋白水平，并研究其与肿瘤临床病理特征的相关性。我们使用酶联免疫吸附测定（ELISA）试剂盒，评估并比较了45例口腔鳞状细胞癌患者血清与45例健康对照样本中OPN的循环水平。与健康对照组（53.9±9.6 ng/ml，n = 45，p <0.001）相比，OSCC患者的血清骨桥蛋白水平显著更高（145.8±14.6 ng/ml，n = 45）。有淋巴结转移的患者（p = 0.03）和更高分期的患者（p = 0.02）的血清骨桥蛋白平均水平显著更高。本研究结果表明，OPN可能在OSCC发病机制中具有潜在作用，并且可作为监测肿瘤进展的工具。
