Hirano T, Manabe T, Tobe T
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Nihon Geka Hokan. 1990 Jul 1;59(4):310-4.
To explore the relationship between exocrine pancreas and parotid gland, we measured the changes of parotid gland in in-vitro system at an acute pancreatitis induced by supramaximal dose of caerulein (5 micrograms/kg/h for 3.5 hours) in rats. Both the serum amylase levels and parotid gland amylase content in rats with acute pancreatitis increased significantly compared with normal rats. The dry/wet weight ratio also decreased significantly and LDH discharge from parotid acini as well as lysosomal enzyme leakage from lysosomes in acini increased significantly compared with normal rats. In addition, redistribution of lysosomal enzyme in parotid acini was seen in acute pancreatitis. These results indicate the edema and congestion of amylase in parotid gland, and furthermore the increased cellular and lysosomal fragility of parotid gland at an acute pancreatitis. Thus, there seems to be the intimate organ relationship between exocrine pancreas and parotid gland as well as the important roles of gut hormones such as caerulein in the pathophysiology of parotid gland.
为了探究外分泌胰腺与腮腺之间的关系，我们在大鼠中用超最大剂量的雨蛙素（5微克/千克/小时，持续3.5小时）诱导急性胰腺炎，在体外系统中测量腮腺的变化。与正常大鼠相比，急性胰腺炎大鼠的血清淀粉酶水平和腮腺淀粉酶含量均显著升高。干/湿重比也显著降低，腮腺腺泡的乳酸脱氢酶释放以及腺泡溶酶体的溶酶体酶泄漏与正常大鼠相比显著增加。此外，在急性胰腺炎中可见腮腺腺泡溶酶体酶的重新分布。这些结果表明腮腺中淀粉酶出现水肿和充血，进而表明急性胰腺炎时腮腺细胞和溶酶体的脆性增加。因此，外分泌胰腺与腮腺之间似乎存在密切的器官关系，以及诸如雨蛙素等肠道激素在腮腺病理生理学中的重要作用。
