小鼠模型中对溶组织内阿米巴的天然抗性。

Innate resistance to Entamoeba histolytica in murine models.

作者信息

Ivory Catherine, Kammanadiminti Srinivas, Chadee Kris

机构信息

Faculty of Medicine, Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.

出版信息

Trends Parasitol. 2007 Feb;23(2):46-8. doi: 10.1016/j.pt.2006.12.006. Epub 2006 Dec 20.

DOI:10.1016/j.pt.2006.12.006

PMID:17185037

Abstract

Hamano et al. have recently reported that in murine models of amebiasis, innate resistance is associated with nonhemopoietic cells and depends on the activity of interleukin-10. This article raises the issue of the importance of predisposition to amebic colitis and discusses which host factors have a role in innate resistance to invasive disease. Resistance studies that elucidate the mechanisms involved in parasite clearance or parasite invasion are essential to understanding the incidence of amebiasis in humans.

摘要

滨野等人最近报道，在阿米巴病的小鼠模型中，先天性抗性与非造血细胞相关，并依赖于白细胞介素-10的活性。本文提出了易患阿米巴结肠炎的重要性问题，并讨论了哪些宿主因素在对侵袭性疾病的先天性抗性中起作用。阐明寄生虫清除或寄生虫侵袭所涉及机制的抗性研究对于理解人类阿米巴病的发病率至关重要。