Fang Song-hua, Zhang Shi-zheng, Liu Hai
Sir Run Shaw Hospital Affiliated to College of Medical Sciences, Zhejiang University, Hangzhou.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Nov;26(11):965-8.
To observe the signal changes of brain functional area during needling Sanyinjiao (ST36), Zusanli (SP6) and Yanglingquan (GB34), the three acupoints in three different meridians, in human by functional magnetic resonance imaging (fMRI), in order to preliminary explore the neural mechanism of acupuncture.
Needling was complemented with 30 s of maneuver applying followed by 30 s of rest as a circle on an acupoint, and at the same time, fMRI was performed once 5 min and 12 s. Then the same program was repeated with the same mode on another acupoint, until ending the experiment.
The commonly activated regions were postcentral gyrus and right inferior frontal gyrus when needling at ST36 and SP6, and the different activated areas included left inferior frontal gyrus, left insula, left inferior parietal lobule, left culmen, left middle temporal gyrus and left middle frontal gyrus, while no cortical signal enhanced region was found when needling at GB34. Signal weakened regions could be found when needling at all the three points, the commonly activated regions were bilateral parahippocampal, hippocampal, callosal gyrus, bilateral praecuneus and cerebellum.
Brain response in special regions could be obtained by needling at different acupoints.
通过功能磁共振成像（fMRI）观察针刺三阴交（ST36）、足三里（SP6）和阳陵泉（GB34）这三个不同经络上的穴位时人脑功能区的信号变化，以初步探讨针刺的神经机制。
针刺时在穴位上以30秒行针随后30秒休息为一个循环，同时每5分12秒进行一次fMRI检查。然后以相同模式在另一个穴位重复相同程序，直至实验结束。
针刺ST36和SP6时，共同激活区域为中央后回和右侧额下回，不同激活区域包括左侧额下回、左侧岛叶、左侧顶下小叶、左侧山顶、左侧颞中回和左侧额中回，而针刺GB34时未发现皮质信号增强区域。针刺这三个穴位时均能发现信号减弱区域，共同激活区域为双侧海马旁回、海马、胼胝体回、双侧楔前叶和小脑。
针刺不同穴位可获得脑特定区域的反应。
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